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Attempted formation of a methoxy-derivative of adduct (09/16/1976 - 09/17/1976)
Purpose/Intro: "The adduct should have a 3-OH group on the aflatoxin moiety. I will try to form the —O-CH3 derivative."
Results/Conclusion: "Chromatogram showed a lot of 254-absorbing crud—and some early-eluting 365. A very sharp peak was observed ~0.4 min earlier than the adduct under these conditions—not known whether this compound is different from the adduct."
Notes: In order to get a mass spectrum of a compound, the sample must "fly," that is, be volatilized. Aflatoxin, since it is large and polar, is not readily volatile and therefore John attemped to reduce the polarity by converting a hydroxyl group to a methoxy group, which would be much less polar.
Links:
PDF: See this in the notebook!
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