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John M Essigmann
Professor in Biological Engineering and Chemistry
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What are your primary research interests?
Chemical carcinogenesis, mutagenesis, chemical basis of evolution, anticancer drug mechanisms of action and design
What was the toughest paper you ever had to write and why?
Lochler et al., 1984. It is the paper for which I was awarded tenure. My scientific career to that point was all working with someone else. This was my first truly independent paper in which I was in charge, from beginning to end, of the team that did the work.
What is your favorite paper and why?
Essigmann et al., 1977. It was a team effort in which I learned a huge amount about working as a member of a team. Also, I was the first author and almost all of the words are my own.
Could you explain how/why you got interested in science and how/why
you chose your particular field within science?
I have always liked solving problems. I had a first rate biology teacher in high school so I majored in biology in college. I went to a coop school and my coop job was in chemistry, which I saw as more promising, career wise, than biology. I worked at Arthur D. Little, a chemistry consulting company. Some of the consulting jobs were at the chemistry-biology interface and I loved them. So, I sought doctoral work at an institution that would allow me to work at that interface. MIT has always had an excellent group of toxicologists and that sub-field seemed perfect for me. It was a good choice.
What is/are your favorite book(s)?
Last of the Breed by Louis L'Amour. Travels with Charley by John Steinbeck. We Took to the Woods by Louise Dickenson Rich
What is/are your favorite movie(s)?
Hoosiers, Eddie and the Cruisers, Apollo 13, Independence Day, The Game
What is/are your favorite food(s)?
Spaghetti and meatballs, turkey, Thai food, pot roast
What are your hobbies and/or interests outside of research?
Housemastering, cooking, skiing, going to our cabin in Maine, kayaking, hiking, learning about a new gizmo (e.g., my Palm 650)
Do you have any special or unusual abilities?
When a key is stuck in a lock, I have a gift for being able to get it out. In another life, I could have been a safecracker. My skills (???) in doing lab work seem to have been directly transferable to cooking. In the dorm, I have to cook for hundreds—cooking and chemistry require the same skill set.